Macalester Lodge participates in a number of philanthropic activities. The most notable is the lodge's participation in the Partners for Life Campaign through Minnesota Masonic Charities, which raises money for the Masonic Cancer Center at the University of Minnesota. Through the Partners for Life Campaign, Macalester Lodge is rated as the only five-star lodge, based on the level of financial commitment from the lodge and its members.

Macalester Lodge also provides scholarships each year to qualified students seeking a higher education and has an almoner's fund available to assist master masons in distress.

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